It's right in the middle of famous and lively Navigli area of Milan, known for its canals by Leonardo Da Vinci. And for its busy night life, but also for vintage shopping and flee markets. The ancient and very characteristic part of Milan with public transportation right at the corner which brings you to Duomo in a few minutes. The subway station close by is Porta Genova. From Central station (train station, arrival busses all airports) it's only a few stops to get directly to Porta Genova.